Heat Biologics, Inc. is a biopharmaceutical company that develops immune therapies and vaccines against cancer and infectious diseases. Its gp96 platform includes ImPACT and ComPACT, which stimulate T-cells. The company's products include HS-110, HS-130, PTX-35, DR3/TNFRSF25, and a COVID-19 vaccine in preclinical stage, and it collaborates with Dr. James Shapiro at University of Alberta to manufacture a surrogate mouse version of PTX-35.